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Process Development Scientist

LocationVancouver, British Columbia
Job ID R0001054 Date posted 10/22/2018

STEMCELL Technologies Inc. is a privately-owned biotechnology company based in Vancouver that helps power leading-edge life science research around the world. Scientists performing stem cell, immunology, cancer, regenerative medicine and cellular therapy research are among those who rely on our cell culture media, cell separation products, instruments, ancillary reagents and contract assay services. We create novel, useful, standardized products of unfailing quality and deliver them to more than 70 countries via our many regional offices plus distribution centres in Vancouver, Seattle, Grenoble and Singapore.  Driven by our love of science and our passion for quality, we see ourselves simply as “Scientists Helping Scientists” – standing by our customers to provide outstanding products, technical support and training.  We have over 1000 science-oriented employees globally, including 250 PhDs/MScs, with most others holding a BSc or engineering degree.  STEMCELL is proud to be the largest Biotechnology employer in Canada.

Job Description Summary

The Process Development Scientist will contribute to a multi-disciplinary team to streamline and lead process development and technology transfer of STEMCELL products from Research and Development (R&D) to the Manufacturing group. The Process Development Scientist will be responsible for the design and optimization of new and existing Manufacturing processes and will act as a Process Development lead in corporate project teams. Must possess a strong desire to teach and mentor junior staff and to help build infrastructure for the evolving functions of the Process Development department.

Job Description

Duties and Responsibilities

  • Responsible for the design, optimization and implementation of upstream process development and scale-up manufacture for the production of proteins, to include the evaluation of microcarrier technology as a scale-up platform

  • Lead Upstream Process Development aspects associated with technology transfer from Research and Development to Manufacturing

  • May be required to assist in the development and scale-up of new and existing protein purification processes

  • Review and optimize processes and process controls for existing products to improve process yields and reduce costs while maintaining product quality.

  • Collaborate with other Process Development teams, RnD, Manufacturing, Analytical and Quality to enhance cross-functional transparency and executional success.

  • Collaborate with RnD and Quality to define critical quality attributes and critical process parameters to set meaningful product specifications, through development batch production, method development and testing.

  • Work with the Manufacturing team to implement new processes, including documentation and technical know-how.

  • Work closely with the Process Engineering team to implement best practices for unit operations of the manufacturing process e.g. filtration techniques

  • Lead root cause investigations and assist in the execution of corrective and preventative actions for process-related non-conformances.

  • Train and mentor junior staff.

  • Provide technical input and directions during capital projects from concept through detailed design.

  • Prepare and review documentation for projects, development and validation studies, and Tech Transfer.

Qualifications

  • BSc in Biology, Biochemistry, Chemical Engineering, Bioengineering or relevant discipline with minimum 7 years of relevant industrial experience or MSc / PhD with minimum 2 years of relevant industrial experience

  • Exposure to ISO 13485 quality management system and cGMPs is an asset

  • Hands-on experience running lab and pilot scale experiments and equipment is required

  • Experience of cell culture and bioreactor operation is required

  • Experience of suspension and adherent cell line scale up is an asset

  • Experience with microcarriers is an asset

  • General knowledge of cell culture media design and troubleshooting is an asset

  • Experience in the downstream purification of proteins is an asset

  • Experience with characterization and assay development of proteins is an asset

  • Good understanding of the challenges associated with scale-up and technology transfer is an asset

  • Must have a strong focus on continuous improvement

  • Must be able to multitask

  • Effective oral and written communication skills, as well as strong interpersonal skills, are required

  • Capable of working effectively in multidisciplinary teams and delivering complex objectives under aggressive timelines

  • Management/supervisory experience is an asset

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

To apply please select the apply button. You will then be directed to a login screen asking you to set up an account. You must set up an account in order to apply. 

Create an account by selecting the create account button.  You will then be asked for your email and to create a password. Your Password must be eight characters long, contain at least one special character, one capital letter, and a number.Once you have created your password you will be asked to upload your resume. Uploading your resume will provide the ability to auto-populate your application with information from your resume. If you prefer to manually complete all of the fields in the application you can do this by clicking next. You can upload your cover letter as an attachment in the attachments screen. Thank you for your interest in STEMCELL!

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