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Process Development Associate, Biologics

LocationVancouver, British Columbia
Job ID R0003586 Date posted 10/22/2021

Job Description Summary

The Process Development Department is looking for three highly motivated Upstream and Downstream Associates to join the Biologics team to support a major cross-functional program. The Biologics team is responsible for technology transfer of new antibodies and recombinant proteins, while creating capacity and maintaining a large existing portfolio used in STEMCELLs Cell Separation and media products. You will work in a dynamic and collaborative team which deals with multiple competing priorities, steers efficiently through prioritization challenges, and has a learning and growth mindset.

Process Development Associates are responsible for conducting scientific data-driven bioprocess development in a fast-paced environment that leads to efficient, robust and scalable protein production processes and their transfer to manufacturing. In this role you will contribute to the design and execution of unit operations across the full workflow, with participation in high-throughput optimization, scale-up activities to bench and pilot scale ahead of technology transfer to Manufacturing teams. If you have experience in antibody bioprocess development, relish solving complex problems, enjoy collaborative relationships across departments, and are looking for opportunities for growth in a fast paced environment, this is the team for you!

Job Description

Duties and Responsibilities

  • Contribute towards development, optimization and implementation of scalable Upstream or Downstream protein (e.g. monoclonal antibodies, fusion proteins) production processes with supervision to meet project timelines.

  • Execute process development studies through high throughput screening methodologies and scale-up to bench and pilot scale operations.

  • Perform protein analytical techniques (e.g. SDS-PAGE, ELISA).

  • Organize and interpret results, presenting to the team at data meetings.

  • Contribute to the Technology Transfer of developed processes to manufacturing production facilities.

  • Support manufacturing operations by reviewing documents and/or using technical expertise to ensure successful manufacturing activities.

  • Author laboratory notebook records, process descriptions/flow charts, process development reports and other documentation/technical reports as needed for progression of assets and/or support of non-conformance investigations (CAPA) or regulatory filings.

  • Contribute to lab upkeep and safety.

Qualifications

  • BSc. in relevant Science or Engineering discipline with 1-4 years of relevant experience or MSc. in relevant Science or Engineering discipline with 0-2 years of relevant experience.

  • Understanding of and hands-on experience with mammalian cell culture of adherent and suspension cell lines is essential (Upstream role).

  • Experience in media/feed development and depth filtration is an asset (Upstream role).

  • Understanding of and hands-on experience with protein purification and filtration methods such as centrifugation, chromatography (i.e. affinity, IEX, and HIC), Dialysis, Depth Filtration, and TFF are essential (Downstream role).

  • Hands-on experience with UF/DF filtration techniques, AKTA systems, and Unicorn software is desirable (Downstream role).

  • Experience with high throughput experimentation and mechanistic modeling, experience with micro, bench, and pilot-scale bioreactors is desirable.

  • Knowledge of protein analytical sciences/method development is an asset.

  • Experience with scale-up/down process models and concepts is an asset.

  • Familiarity with software such as MS Excel, Google Sheets, JMP, GraphPad is desirable.

  • Ability to foster a collaborative work environment with internal and external partners is desirable.

This role requires vaccination against COVID-19 as per the current recommendations by local health authorities, including any COVID-19 boosters as recommended by local health authorities and where available.

#Bench

    STEMCELL Technologies Inc. is a privately-owned biotechnology company based in Vancouver that helps power leading-edge life science research around the world. Scientists performing stem cell, immunology, cancer, regenerative medicine and cellular therapy research are among those who rely on our cell culture media, cell separation products, instruments, ancillary reagents and contract assay services. We create novel, useful, standardized products of unfailing quality and deliver them to more than 70 countries via our many regional offices plus distribution centres in Vancouver, Seattle, Grenoble and Singapore.  Driven by our love of science and our passion for quality, we see ourselves simply as “Scientists Helping Scientists” – standing by our customers to provide outstanding products, technical support and training.  We have over 1000 science-oriented employees globally, including 250 PhDs/MScs, with most others holding a BSc or engineering degree.  STEMCELL is proud to be the largest Biotechnology employer in Canada.

    This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

    To apply please select the apply button. You will then be directed to a login screen asking you to set up an account. You must set up an account in order to apply. 

    Create an account by selecting the create account button.  You will then be asked for your email and to create a password. Your Password must be eight characters long, contain at least one special character, one capital letter, and a number.Once you have created your password you will be asked to upload your resume. Uploading your resume will provide the ability to auto-populate your application with information from your resume. If you prefer to manually complete all of the fields in the application you can do this by clicking next. You can upload your cover letter as an attachment in the attachments screen. Thank you for your interest in STEMCELL!

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