Early Stage Researcher
Job Description Summary
STEMCELL is continuing to expand its European operations, particularly in the areas of R&D personnel and facilities, manufacturing, quality control, quality assurance and regulatory activities that will meet the highest levels of European research and regular standards. STEMCELL UK Ltd. (STUK) was established in July 2014. In 2016 STUK expanded its capabilities to include research and development (R&D) with staff located in laboratory space in Cambridge, UK, including fully functional laboratory space containing state of the art cell culture and analytical chemistry equipment as well as an ISO 13485-certified manufacturing clean room that is adopting single use technology and closed systems for manufacturing higher compliance media and culture reagents.
Project title: Generation of neural crest cells from patient-derived hiPSCs for disease modeling and therapeutic applications.
Host institution: STEMCELL Technologies UK Ltd. Cambridge, UK
This project focuses on differentiation of neural crest cells to various downstream cell types including bone, cartilage and fat. During this project, you will be focusing on the following research objectives:
Standardize protocols for neural crest (NC) induction (conditions, stages, set of marker genes) for use by the Network Partners.
Establish high-throughput, high-content cell migration assays of induced NC
Establish high content cell profiling assays of ciliopathic hiPSCs induced in NC and differentiated towards craniofacial bone and cartilage lineages
This project also includes two six-month secondments with The Institut Curie (Paris, France) focusing on gene regulatory networks and at Phenocell (Grasse, France) focusing on candidate gene screening using gene editing.
You will be guided during your research project by Dr. Erin Knock (Neural research specialist at STEMCELL Technologies Vancouver), Dr. Wing Chang (Pluripotent Stem cell specialist at STEMCELL Technologies UK) and Prof Karen Liu (Professor of Genetics and Development, King’s College London).
- Have a recent Master degree or equivalent research experience in the field of stem cell biology, human genetics, or development
- Interest and experience in hPSC culture and microscopy is an advantage
- Proficient in the English language with excellent communication skills (verbal and written)
- Highly motivated and enthusiastic
- Flexible, independent and pro-active
- Real team player with great team spirit
- Problem-solving and organizational skills
- Highly accurate with attention to detail
- Have obtained high grades during her/his studies
1) Early-stage researchers (ESR) are those who are, at the time of recruitment by the host institution, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged.
2) Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of selection by the host institution, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.
Location: Cambridge Research Park Waterbeach, UK
Start date: 6 January, 2020 (3-year research position)
Salary: £33-40K per annum
Closing Date for applications: 15 November, 2019
NO AGENTS OR CALLERS
NEUcrest is an Innovative Training Network (ITN) project, funded by the European Union Horizon 2020 Programme. The neural crest (NC) is an essential stem cell population of the vertebrate embryos that gives rise to various tissues in the body such as the cranial facial cartilage, peripheral nervous system and the Adrenal Medulla. NEUcrest focuses on integrating academic, clinical and industrial research for a better understanding of neural crest development and neural crest related diseases called Neurocristopathies. These pathologies are a major group of congenital diseases in human, and a heavy societal concern. The NEUcrest network comprises 20 partners in academia, industry and hospitals from seven European countries, gathered in a synergistic effort to advance knowledge and outreach about these diseases.
With an exceptionally rich training environment and regular network-wide events, our aim is to train 15 PhD students to be part of the next generation of leading European young scientists, highly proficient in the multidisciplinary range of scientific skills and technological expertise required for a comprehensive view of development and diseases : developmental and stem cell biology, cell and molecular biology, cancer biology, imaging, bioinformatics, human and animal genetics, and drug screening.
In addition to the excellent doctoral training that each beneficiary will follow at his/her University, the network will provide an active training environment, by bringing together selected partners from the academic, industrial and communication sectors, and will stimulate fruitful interactions between the NEUcrest PhD students themselves through regular network-wide events.
There will also be a strong emphasis on communication skills and public/patient/clinician outreach. Thus, the NEUcrest ITN will enable the selected PhD students to master scientific and transferable competences indispensable for addressing complex questions in Life Sciences and Human Health, and position them for leading roles in European academia and industry.
STEMCELL Technologies Inc. is a privately-owned biotechnology company based in Vancouver that helps power leading-edge life science research around the world. Scientists performing stem cell, immunology, cancer, regenerative medicine and cellular therapy research are among those who rely on our cell culture media, cell separation products, instruments, ancillary reagents and contract assay services. We create novel, useful, standardized products of unfailing quality and deliver them to more than 70 countries via our many regional offices plus distribution centres in Vancouver, Seattle, Grenoble and Singapore. Driven by our love of science and our passion for quality, we see ourselves simply as “Scientists Helping Scientists” – standing by our customers to provide outstanding products, technical support and training. We have over 1000 science-oriented employees globally, including 250 PhDs/MScs, with most others holding a BSc or engineering degree. STEMCELL is proud to be the largest Biotechnology employer in Canada.
This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.
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